(venv) ➜  ~ pip list --format=columns | grep urllib3
urllib3                      1.22    

(venv) ➜  ~ python
Python 2.7.10 (default, Jul 14 2015, 19:46:27) 
[GCC 4.2.1 Compatible Apple LLVM 6.0 (clang-600.0.39)] on darwin
Type "help", "copyright", "credits" or "license" for more information.
>>> import urllib3
>>> http = urllib3.PoolManager(cert_reqs='CERT_REQUIRED')
>>> r = http.request('GET', 'https://github.com/')
>>> print r.status
200
>>> r = http.request('GET', 'https://github.com./')
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/request.py", line 66, in request
    **urlopen_kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/request.py", line 87, in request_encode_url
    return self.urlopen(method, url, **extra_kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/poolmanager.py", line 321, in urlopen
    response = conn.urlopen(method, u.request_uri, **kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/connectionpool.py", line 668, in urlopen
    **response_kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/connectionpool.py", line 668, in urlopen
    **response_kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/connectionpool.py", line 668, in urlopen
    **response_kw)
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/connectionpool.py", line 639, in urlopen
    _stacktrace=sys.exc_info()[2])
  File "/Users/karteek/venv/lib/python2.7/site-packages/urllib3/util/retry.py", line 388, in increment
    raise MaxRetryError(_pool, url, error or ResponseError(cause))
urllib3.exceptions.MaxRetryError: HTTPSConnectionPool(host='github.com.', port=443): Max retries exceeded with url: / (Caused by SSLError(CertificateError("hostname 'github.com.' doesn't match either of 'github.com', 'www.github.com'",),))

curl -v https://github.com./ 
*   Trying 192.30.255.112...
* Connected to github.com (192.30.255.112) port 443 (#0)
* TLS 1.2 connection using TLS_ECDHE_RSA_WITH_AES_128_CBC_SHA256
* Server certificate: github.com
* Server certificate: DigiCert SHA2 Extended Validation Server CA
* Server certificate: DigiCert High Assurance EV Root CA
> GET / HTTP/1.1
> Host: github.com
> User-Agent: curl/7.43.0
> Accept: */*
> 
< HTTP/1.1 200 OK
< Date: Thu, 31 Aug 2017 21:06:01 GMT
< Content-Type: text/html; charset=utf-8
< Transfer-Encoding: chunked
< Server: GitHub.com
< Status: 200 OK
< Cache-Control: no-cache