I'm running pip-compile under OS X and have a requirements/dev.in file which includes IPython. This pulls in gnureadline. When I build a pex (https://github.com/pantsbuild/pex) from this requirements file for a Linux system, it's not usable, because gnureadline is only available for OS X.

I can work around this by removing or commenting out the gnureadline dependency, but this is a bit hacky. It would be great to be able to do: pip-compile requirements/base.in && pip-compile requirements/dev.in && pip-compile --remove gnureadline requirements/stage.in.