https://prow.istio.io/view/gs/istio-prow/pr-logs/pull/istio_istio/37162/integ-pilot-istiodremote_istio/1489422911918837760

Here

This is a pod IP
Istiod autoscales up to 2 pods, because the istiodless code doesn't set the same config as in cluster (which has autoscaling disable)
We picked the wrong istiod in that code above, so we hit an istiod with 0 connections and fail