There is an area on the right hand side of the screen where if the cursor is within it, it will get heavily distorted.

This may also be the cause of another issue, in which the cursor turns into a blank box and the capture stops updating, this only happens on some monitors, and only affects that one monitor. Re-initializing the API will fix that.

Here's a log from another users system that has a bunch of CreateTexture2D() failed. and Map() failed in it.

uDesktopDuplication.log