The way selection currently works in VS Code requires you to hold down the shift key while holding down the arrow keys or using "Home", "End" and other such keys to contiguously select blocks of text/code.
While this works for most cases, this can become rather cumbersome for screen reader users when large amounts of code need to be acted on at once, e.g. copied, deleted etc.
The main cause of this is that screen readers pretty much require keyboard shortcuts to be used to get anything done. Quickly checking down a few lines (screen readers only see one line at a time), checking context, various other things are pretty much impossible while you are trying to select a large piece of code.
This is especially painful, for example, when you have a large amount of dummy HTML that needs to be replaced by a dynamic loop. Checking if you managed to get 6 levels worth of nested divs rather than that one outer div you didn't mean to highlight becomes an exercise in frustration.

A way around this problem is to, rather than depend on a held down key for contiguous selection, use a single keypress to mark the beginning and another to mark the end of the wanted selection. Once both points are set, the text in between those points is highlighted and can then be acted on.
This frees the keyboard up to , for example, move around the file, etc. without ever losing your selection
@isidorn requested to be notified of this feature request being created.