I just checked the most common py_method_call in mypy and it looks like many could be removed by adding some primitive ops..

• 18 ('replace') PyUnicode_Replace
• 19 ('write')
• 20 ('clear') PyDict_Clear
• 20 ('copy') PyDict_Copy/..
• 23 ('setdefault') PyDict_SetDefault
• 32 ('keys') (Faster dict iteration #167)
• 33 ('strip')
• 38 ('endswith') PyUnicode_Tailmatch
• 49 ('values') (Faster dict iteration #167)
• 50 ('startswith') PyUnicode_Tailmatch
• 73 ('split') PyUnicode_Split
• 100 ('join') PyUnicode_Join
• 118 ('items') (Faster dict iteration #167)
• 535 ('format') (Faster string formatting #724)

1455 total

Some of these would not be correct for subclasses of dict. str etc. This can either be handwaved away, or not.