An R package for polygenic risk score (PRS) generation that applies multivariate adaptive regression splines (MARS) to integrate genetic information from multiple related traits. The pipeline uses PCA-based variant transformations and a unique genotype-level cross-validation approach, eliminating the need for participant-level train/test split.

Utilities for linear regression-based statistical computation, particularly in the same vein as methods like MonsterLM and RARity

Utilities for linear regression-based statistical computation, particularly in the same vein as methods like MonsterLM and RARity

Generate beautiful forest plots with ease

A heritability-optimized scoring method using multivariate adaptive regression splines that incorporates 75 variant- and gene-level features. RovHer leverages exome-wide association statistics to train models estimating the probability of RV functional impact.

An R-based software package which automates a stratified Mendelian randomization (MR) algorithm designed to identify effect modifiers of causal relationships

A method to estimate rare variant heritability. Its versatility lies in the ability to estimate both gene-level and exome-wide heritability, in a fast, accurate, and unbiased manner.